Recent developments in the global arena have accentuated the vulnerabilities of supply chains and highlighted the imperative for a smooth and efficient flow of goods and services that is impervious to localized disruptions. Unexpected choke points in supply chains, volatile prices, and unavailability of goods impact the development trajectories of economies across the world. Keeping trade open across borders and establishing coordinated mechanisms for risk monitoring and crisis foresight will be crucial to preventing future roadblocks. The mission of development, particularly for least developed countries which are most at risk with limited access to critical assets, must aim at building the resilience to structural economic shocks arising from supply chain disruptions. Nations must focus on ensuring that trade and integration into global value chains acts as a potent instrument of growth for all countries.